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经颅直流电刺激对精神分裂症患者认知、症状和吸烟的影响

作者:乐风 来源:医学论坛网 日期:2015-08-05
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         经颅直流电刺激对精神分裂症患者认知、症状和吸烟的影响

Schizophr Res. 2015 Jul 16. pii: S0920-9964(15)00326-6. doi: 10.1016/j.schres.2015.06.011. [Epub ahead of print]

Effects of transcranial direct current stimulation (tDCS) on cognition, symptoms, and smoking in schizophrenia: A randomized controlled study.经颅直流电刺激精神分裂症患者认知、症状和吸烟的影响:一项随机对照研究

Smith RC1Boules S2Mattiuz S3Youssef M4Tobe RH5Sershen H6Lajtha A7Nolan K8Amiaz R9Davis JM10.

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Abstract

Schizophrenia is characterized by cognitive deficits which persist after acute symptoms have been treated or resolved. Transcranial direct current stimulation (tDCS) has been reported to improve cognition and reduce smoking craving in healthy subjects but has not been as carefully evaluated in a randomized controlled study for these effects in schizophrenia. We conducted a randomized double-blind, sham-controlled study of the effects of 5 sessions of tDCS (2 milliamps for 20minutes) on cognition, psychiatric symptoms, and smoking and cigarette craving in 37 outpatients with schizophrenia or schizoaffective disorder who were current smokers. Thirty subjects provided evaluable data on the MATRICS Consensus Cognitive Battery (MCCB), with the primary outcome measure, the MCCB Composite score. Active compared to sham tDCS subjects showed significant improvements after the fifth tDCS session in MCCB Composite score (p=0.008) and on the MCCB Working Memory (p=0.002) and Attention-Vigilance (p=0.027) domain scores, with large effect sizes. MCCB Composite and Working Memory domain scores remained significant at Benjamini-Hochberg corrected significance levels (α=0.05). There were no statistically significant effects on secondary outcome measures of psychiatric symptoms (PANSS scores), hallucinations, cigarette craving, or cigarettes smoked. The positive effects of tDCS on cognitive performance suggest a potential efficacious treatment for cognitive deficits in partially recovered chronic schizophrenia outpatients that should be further investigated.

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